Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31591781 | 1.00 | KMT2A (0.71) | KMT2ARXFP1ADORA2AADORA1ADORA2B | |
| SCHEMBL22208277 | 0.87 | ADORA1 (0.66) | KMT2ARXFP1ADORA2AADORA1ADORA2B | |
| SCHEMBL20570773 | 0.83 | KMT2A (1.00) | KMT2ARXFP1ADORA2AADORA1ADORA2B | |
| SCHEMBL23851984 | 0.83 | KMT2A (0.71) | KMT2ARXFP1ADORA2AADORA1ADORA2B | |
| SCHEMBL32688280 | 0.77 | ADORA1 (0.58) | KMT2AADORA2AADORA1ADORA2BMEN1 | |
| SCHEMBL20041347 | 0.75 | ADORA1 (0.77) | KMT2ARXFP1ADORA2AADORA1MEN1 | |
| SCHEMBL17131839 | 0.73 | ADORA1 (0.53) | KMT2AADORA2AADORA1ADORA2BMEN1 | |
| SCHEMBL19665238 | 0.71 | ADORA1 (0.69) | ADORA2AADORA1ADORA2BHSD17B10 | |
| SCHEMBL7100991 | 0.71 | KDM4E (0.58) | KMT2ARXFP1ADORA2AADORA1ADORA2B | |
| SCHEMBL25992022 | 0.71 | ADORA1 (0.63) | KMT2ARXFP1ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883577-B1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | UNIV CASE WESTERN RESERVE (US) | 2026-04-08 | — | — | EP | disclosed |
| US-12336982-B2 | Compositions and methods of modulating short-chain dehydrogenase activity | RODEO THERAPEUTICS CORPORATION (US) | 2025-06-24 | — | — | US | disclosed |
| US-20250161277-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2025-05-22 | — | — | US | disclosed |
| US-20230039604-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | RODEO THERAPEUTICS CORPORATION | 2023-02-09 | — | — | US | disclosed |
| US-20230039604-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | RODEO THERAPEUTICS CORPORATION | 2023-02-09 | — | — | US | disclosed |
| CN-113507931-A | Compositions and methods for modulating short-chain dehydrogenase activity | 卡斯西部储备大学 | 2021-10-15 | — | — | CN | disclosed |
| EP-3883577-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2021-09-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250161277-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | HPGD, GCDH, HPGDS | KMT2A 3903/4885RXFP1 3781/4885ADORA2A 1966/4885 |
| US-12336982-B2 | Compositions and methods of modulating short-chain dehydrogenase activity | HPGD, GCDH, HPGDS | KMT2A 3903/4885RXFP1 3781/4885ADORA2A 1966/4885 |
| US-20230039604-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | HPGD, GCDH, HPGDS | KMT2A 3903/4885RXFP1 3781/4885ADORA2A 1966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.