SCHEMBL23852895

SCHEMBL23852895

CCOC(=O)c1nn(Cc2ccc(C)cc2)c2c1CCCC2=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNA2 P20248 2/20 0.48
CDK2 P24941 2/20 0.48
CCNA1 P78396 2/20 0.48
CYP19A1 P11511 3/20 0.47
NPC1 O15118 2/20 0.46
LMNA P02545 2/20 0.46
ALDH1A1 P00352 4/20 0.44
SMN1; SMN2 Q16637 3/20 0.43
TDP1 Q9NUW8 1/20 0.43
PDE4A P27815 2/20 0.42
PDE4B Q07343 2/20 0.42
PDE4C Q08493 2/20 0.42
PDE4D Q08499 2/20 0.42
KDM4E B2RXH2 1/20 0.41
TP53 P04637 1/20 0.41
HPGD P15428 1/20 0.41
HSD17B10 Q99714 1/20 0.41
RAB9A P51151 1/20 0.40
CNR2 P34972 2/20 0.40
GAA P10253 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23853852 0.91 CYP19A1 (0.49) CCNA2CDK2CCNA1CYP19A1NPC1
SCHEMBL4162934 0.91 CYP19A1 (0.53) CYP19A1ALDH1A1SMN1; SMN2TDP1PDE4A
SCHEMBL9940587 0.90 CCNA2 (0.50) CCNA2CDK2CCNA1CYP19A1ALDH1A1
SCHEMBL23853798 0.89 CA1 (0.42) CCNA2CDK2CCNA1CYP19A1NPC1
SCHEMBL23853519 0.87 SMN1; SMN2 (0.46) CCNA2CDK2CCNA1CYP19A1NPC1
SCHEMBL3502692 0.83 BRD4 (0.45) CCNA2CDK2CCNA1LMNAALDH1A1
SCHEMBL2912693 0.82 CNR2 (0.60) CCNA2CDK2CCNA1CNR2
SCHEMBL2911590 0.82 CNR2 (0.60) CCNA2CDK2CCNA1CYP19A1NPC1
SCHEMBL21995756 0.81 BRD4 (0.43) CCNA2CDK2CCNA1LMNAALDH1A1
SCHEMBL4159155 0.80 LMNA (0.42) CCNA2CDK2CCNA1LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3883931-A1 HETEROCYCLIC COMPOUNDS AND MEDICAL USE THEREOF Fondazione Telethon (IT) 2021-09-29 EP disclosed