Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19331175 | 1.00 | POLB (0.46) | POLBHCAR2ABCG2MEN1NPC1 | |
| SCHEMBL19331172 | 1.00 | POLB (0.46) | POLBHCAR2ABCG2MEN1NPC1 | |
| SCHEMBL19331154 | 0.90 | POLB (0.34) | POLBHCAR2ABCG2MEN1NPC1 | |
| SCHEMBL19331152 | 0.90 | POLB (0.34) | POLBHCAR2ABCG2MEN1NPC1 | |
| SCHEMBL19343279 | 0.89 | POLB (0.45) | POLBHCAR2ABCG2MEN1NPC1 | |
| SCHEMBL19330913 | 0.89 | POLB (0.34) | POLBHCAR2MEN1NPC1GAA | |
| SCHEMBL29062787 | 0.84 | KDM4E (0.39) | POLBNPC1RAB9AKMT2AMAPT | |
| SCHEMBL19343821 | 0.79 | POLB (0.34) | POLBHCAR2MEN1GAARAB9A | |
| SCHEMBL19343493 | 0.78 | MAPT (0.33) | POLBMEN1GAAKMT2AMAPT | |
| SCHEMBL27908802 | 0.77 | MAPT (0.45) | POLBABCG2MEN1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3884939-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | Raze Therapeutics, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |