Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23495234 | 0.78 | KDM4E (0.62) | KMT2AALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL23495158 | 0.78 | KDM4E (0.62) | KMT2AALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL23495325 | 0.78 | ALDH1A1 (0.58) | KMT2AALDH1A1MAPTUSP2MAPK1 | |
| SCHEMBL23495470 | 0.78 | ALDH1A1 (0.58) | KMT2AALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL25183780 | 0.77 | MAPK1 (0.52) | KMT2AALDH1A1TDP1KDM4EPOLB | |
| SCHEMBL23495174 | 0.76 | KDM4E (0.63) | KMT2AALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL23495210 | 0.76 | ALDH1A1 (0.59) | KMT2AALDH1A1MAPTUSP2MAPK1 | |
| SCHEMBL23495345 | 0.76 | ALDH1A1 (0.59) | KMT2AALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL25192629 | 0.76 | USP2 (0.53) | KMT2AALDH1A1TDP1KDM4EPOLB | |
| SCHEMBL23495312 | 0.76 | USP2 (0.73) | KMT2AALDH1A1KDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3884948-A1 | CATHEPSIN INHIBITORS AND USES THEREOF | Ecole Polytechnique Fédérale de Lausanne (EPFL) (CH) | 2021-09-29 | — | — | EP | claimed |
| WO-2021191412-A1 | CATHEPSIN SUBSTRATES & CATHEPSIN INHIBITORS AND USES THEREOF | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2021-09-30 | — | — | WO | disclosed |
| EP-3884948-A1 | CATHEPSIN INHIBITORS AND USES THEREOF | Ecole Polytechnique Fédérale de Lausanne (EPFL) (CH) | 2021-09-29 | — | — | EP | disclosed |
| EP-3884948-A1 | CATHEPSIN INHIBITORS AND USES THEREOF | Ecole Polytechnique Fédérale de Lausanne (EPFL) (CH) | 2021-09-29 | — | — | EP | disclosed |