Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.39 |
| ▸ | CKS1B | P61024 | 2/20 | 0.38 |
| ▸ | SKP1 | P63208 | 2/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23854157 | 1.00 | HPGDS (0.42) | HPGDSUSP30CKS1BSKP1SKP2 | |
| SCHEMBL23854156 | 1.00 | HPGDS (0.42) | HPGDSUSP30CKS1BSKP1SKP2 | |
| SCHEMBL24129963 | 0.90 | HPGDS (0.42) | HPGDSUSP30CKS1BSKP1SKP2 | |
| SCHEMBL23854215 | 0.88 | HPGDS (0.41) | HPGDSUSP30CKS1BSKP1SKP2 | |
| SCHEMBL23854217 | 0.88 | HPGDS (0.41) | HPGDSUSP30CKS1BSKP1SKP2 | |
| SCHEMBL24129983 | 0.88 | HPGDS (0.41) | HPGDSUSP30CKS1BSKP1SKP2 | |
| SCHEMBL24129982 | 0.83 | ADORA2A (0.43) | ADORA2A | |
| SCHEMBL23852060 | 0.77 | P2RY12 (0.35) | ADORA2AGABRA5 | |
| SCHEMBL23853840 | 0.77 | P2RY12 (0.35) | ADORA2A | |
| SCHEMBL23851820 | 0.77 | P2RY12 (0.35) | ADORA2AGABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883575-A1 | SUBSTITUTED AMINO TRIAZOLOPYRIMIDINE AND AMINO TRIAZOLOPYRAZINE ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE | Merck Sharp & Dohme Corp. (US) | 2021-09-29 | — | — | EP | disclosed |