Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.52 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.50 |
| ▸ | AKT1 | P31749 | 5/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31111409 | 0.83 | ADORA2A (0.59) | KIF18AAKT1PIK3CBPIK3CDPIK3CA | |
| SCHEMBL23275363 | 0.83 | ADORA2A (0.59) | KIF18AAKT1PIK3CBPIK3CDPIK3CA | |
| SCHEMBL971475 | 0.77 | KCNQ3 (0.68) | KCNQ3KCNQ2AKT1MAPTPOLB | |
| SCHEMBL971843 | 0.77 | KCNQ3 (0.59) | KCNQ3KCNQ2AKT1PIK3CBPIK3CD | |
| SCHEMBL30796083 | 0.77 | KCNQ3 (0.68) | KCNQ3KCNQ2AKT1MAPTPOLB | |
| SCHEMBL30794774 | 0.77 | KCNQ3 (0.59) | KCNQ3KCNQ2AKT1PIK3CBPIK3CD | |
| SCHEMBL30824695 | 0.77 | KCNQ2 (0.56) | KCNQ3KCNQ2AKT1PIK3CBPIK3CD | |
| SCHEMBL970263 | 0.77 | KCNQ2 (0.56) | KCNQ3KCNQ2AKT1PIK3CBPIK3CD | |
| SCHEMBL23275157 | 0.73 | POLB (0.48) | KIF18APIK3CBPIK3CDPIK3CAMAPT | |
| SCHEMBL29762362 | 0.73 | POLB (0.48) | KIF18APIK3CBPIK3CDPIK3CAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12312336-B2 | Inhibitors of RAF kinases | Pierre Fabre Médicament (FR) | 2025-05-27 | — | — | US | disclosed |
| EP-4048259-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-08-31 | — | — | EP | disclosed |
| US-20210300904-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300904-A1 | INHIBITORS OF RAF KINASES | BRAF, RAF1, ARAF | KIF18A 2665/4885KCNQ3 4288/4885KCNQ2 4021/4885 |
| US-12312336-B2 | Inhibitors of RAF kinases | BRAF, RAF1, ARAF | KIF18A 2665/4885KCNQ3 4288/4885KCNQ2 4021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.