Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.32 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2385466 | 1.00 | NFE2L2 (0.38) | NFE2L2MAOBACMSDHCRTR1HCRTR2 | |
| SCHEMBL637405 | 0.97 | NFE2L2 (0.37) | NFE2L2MAOBACMSDHCRTR1HCRTR2 | |
| SCHEMBL4402151 | 0.93 | MAOB (0.38) | NFE2L2MAOBACMSDPKMABL1 | |
| SCHEMBL634664 | 0.93 | MAOB (0.38) | NFE2L2MAOBACMSDPKMABL1 | |
| SCHEMBL16966567 | 0.93 | EDNRA (0.38) | ACMSDPKMMAPTTP53EDNRA | |
| SCHEMBL635663 | 0.92 | HCRTR1 (0.36) | MAOBACMSDHCRTR1HCRTR2PKM | |
| SCHEMBL4401364 | 0.92 | HCRTR1 (0.36) | MAOBACMSDHCRTR1HCRTR2PKM | |
| SCHEMBL636245 | 0.91 | HCRTR1 (0.41) | HCRTR1HCRTR2 | |
| SCHEMBL2372230 | 0.91 | HCRTR1 (0.41) | HCRTR1HCRTR2 | |
| SCHEMBL6032767 | 0.91 | HCRTR1 (0.37) | ACMSDHCRTR1HCRTR2PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283017-B1 | FUSED PYRIMIDINEONE COMPOUNDS AS TRPV3 MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2015-08-05 | — | — | EP | claimed |
| US-20130203778-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A PYRIMIDINEONE DERIVATIVE | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-08-08 | — | — | US | disclosed |
| EP-2549998-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A PYRIMIDINEONE DERIVATIVE | Glenmark Pharmaceuticals S.A. (CH) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011117711-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A PYRIMIDINEONE DERIVATIVE | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203778-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A PYRIMIDINEONE DERIVATIVE | GPR17, P2RY2, ABCG2 | NFE2L2 3778/4885MAOB 2057/4885ACMSD 4655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.