Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ARG1 | P05089 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21645102 | 1.00 | DPP4 (0.45) | DPP4DPP7PREPLMNADPP8 | |
| SCHEMBL4693217 | 0.88 | DPP4 (0.46) | DPP4DPP7PREPLMNADPP8 | |
| SCHEMBL3930489 | 0.84 | LMNA (0.47) | DPP4DPP7PREPLMNADPP8 | |
| SCHEMBL4756275 | 0.82 | LMNA (0.49) | LMNAALDH1A1MEN1KMT2AGAA | |
| SCHEMBL4754510 | 0.82 | LMNA (0.49) | LMNAALDH1A1MEN1KMT2AGAA | |
| SCHEMBL4757581 | 0.82 | LMNA (0.49) | LMNAALDH1A1MEN1KMT2AGAA | |
| SCHEMBL22519412 | 0.81 | KMT2A (0.59) | DPP4DPP7PREPLMNAMEN1 | |
| SCHEMBL21661021 | 0.81 | DPP4 (0.41) | DPP4DPP7PREPDPP8DPP9 | |
| SCHEMBL21431189 | 0.81 | DPP4 (0.48) | DPP4DPP7PREPDPP8DPP9 | |
| SCHEMBL23866612 | 0.81 | KMT2A (0.59) | DPP4DPP7PREPLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | DPP4 1190/4885DPP7 461/4885PREP 3456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.