SCHEMBL2385641

SCHEMBL2385641

C1=CCCC2C3C=CC(C3)C2CC1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.44
HSD11B1 P28845 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2385638 1.00 ALDH1A1 (0.44) ALDH1A1HSD11B1
SCHEMBL2968750 0.97 ALDH1A1 (0.42) ALDH1A1HSD11B1
SCHEMBL2968747 0.97 ALDH1A1 (0.42) ALDH1A1HSD11B1
SCHEMBL5491384 0.81
SCHEMBL19689443 0.81 ALDH1A1 (0.46) ALDH1A1HSD11B1
SCHEMBL1066229 0.79 ALDH1A1 (0.33) ALDH1A1
SCHEMBL676880 0.79 ALDH1A1 (0.60) ALDH1A1
SCHEMBL14837405 0.78 ALDH1A1 (0.52) ALDH1A1
SCHEMBL5862989 0.76 ALDH1A1 (0.45) ALDH1A1HSD11B1
SCHEMBL5862993 0.76 ALDH1A1 (0.45) ALDH1A1HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7666966-B2 Method of manufacturing thermoplastic resin, crosslinked resin, and crosslinked resin composite material ZEON CORPORATION (JP) 2010-02-23 US claimed
US-20120241250-A1 Aerial Work Platforms and Aerial Work Platform Assemblies Comprised of Polymerized Cycloolefin Monomers EAKIN GEORGE R (US) 2012-09-27 US disclosed
US-8013090-B2 Film comprising norbornene compound addition polymer ZEON CORPORATION (JP) 2011-09-06 US disclosed
US-7771834-B2 Method of manufacturing thermoplastic resin, crosslinked resin, and crosslinked resin composite material ZEON CORPORATION (JP) 2010-08-10 US disclosed
US-7666966-B2 Method of manufacturing thermoplastic resin, crosslinked resin, and crosslinked resin composite material ZEON CORPORATION (JP) 2010-02-23 US disclosed
US-20090275719-A1 Film Comprising Norbornene Compound Addition Polymer ZEON CORPORATION (JP) 2009-11-05 US disclosed
US-20090036614-A1 METHOD OF MANUFACTURING THERMOPLASTIC RESIN, CROSSLINKED RESIN, AND CROSSLINKED RESIN COMPOSITE MATERIAL ZEON CORPORATION 2009-02-05 US disclosed
US-7476716-B2 Method of manufacturing thermoplastic resin, crosslinked resin, and crosslinked resin composite material ZEON CORPORATION (JP) 2009-01-13 US disclosed
EP-1535941-B1 PROCESSES FOR PRODUCING THERMOPLASTIC RESINS, CROSSLINKED RESINS AND CROSSLINKED RESIN COMPOSITE MATERIALS ZEON CORP (JP) 2007-09-12 EP disclosed
US-20070191563-A1 Method of manufacturing thermoplastic resin, crosslinked resin, and crosslinked resin composite material ZEON CORPORATION (JP) 2007-08-16 US disclosed
EP-1706374-A2 NORBORNANE BASED CYCLOALIPHATIC COMPOUNDS CONTAINING NITRILE GROUPS INVISTA NORTH AMERICA S.A R.L. (US) 2006-10-04 EP disclosed
US-20060211834-A1 Method of manufacturing thermoplastic resin, crosslinked resin, and crosslinked resin composite material ZEON CORPORATION (JP) 2006-09-21 US disclosed
US-20060166511-A1 Method for treatment of film or sheet JSR CORPORATION (JP) 2006-07-27 US disclosed
WO-2005075412-A2 NORBORNANE BASED CYCLOALIPHATIC COMPOUNDS CONTAINING NITRILE GROUPS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2005-08-18 WO disclosed
US-20050159614-A1 Norbornane based cycloaliphatic compounds containing nitrile groups E. I. DU PONT DE NEMOURS AND COMPANY 2005-07-21 US disclosed
US-6677175-B2 CURING A CLADDING LAYER TO FORM A CORE/CLADDING COMBINATION AND REMOVING THE CORE/CLADDING TO EXPOSE A PORTION OF THE CORE THAT HAS REFRACTIVE INDEX .05% HIGHER THAN THE CURED CLADDING COMPOSITION PROMERUS, LLC 2004-01-13 US disclosed
US-20020103317-A1 Polymeric compositions for forming optical waveguides; optical waveguides formed therefrom; and methods for making same SUMITOMO BAKELITE CO., LTD. (JP) 2002-08-01 US disclosed
US-20020064896-A1 Optical waveguides and methods for making the same 3M INNOVATIVE PROPERTIES COMPANY 2002-05-30 US disclosed
US-6350832-B1 CATALYTIC COSSLINKING POLYMER OF POLYCYCLOOLEFIN MONOMER, MOLDING AND SHAPING IN THE PRESENCE OF GROUP 10 TRANSITION METAL AND ANION THE B. F. GOODRICH COMPANY 2002-02-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050159614-A1 Norbornane based cycloaliphatic compounds containing nitrile groups NISCH, PAH, CYP1B1 ALDH1A1 2222/4885HSD11B1 66/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.