Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 11/20 | 0.46 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.35 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17734416 | 0.88 | EZH2 (0.44) | PDE9AEZH2EEDSUZ12 | |
| SCHEMBL17734412 | 0.77 | EZH2 (0.55) | EZH2EEDSUZ12 | |
| SCHEMBL17734418 | 0.74 | EZH2 (0.56) | EZH2EEDSUZ12 | |
| SCHEMBL23863703 | 0.73 | EZH2 (0.52) | EZH2EEDSUZ12 | |
| SCHEMBL24227152 | 0.72 | EZH2 (0.45) | PDE9AEZH2EEDSUZ12 | |
| SCHEMBL17734356 | 0.64 | EZH2 (0.57) | EZH2EEDSUZ12 | |
| SCHEMBL17734413 | 0.63 | EZH2 (0.71) | EZH2EEDSUZ12 | |
| SCHEMBL20621469 | 0.63 | EZH2 (0.71) | EZH2EEDSUZ12 | |
| SCHEMBL12399438 | 0.63 | PDE9A (1.00) | PDE9A | |
| SCHEMBL20621515 | 0.62 | EZH2 (0.56) | EZH2EEDSUZ12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3885343-A1 | INDOLE COMPOUNDS AS EZH2 INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |