Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 12/20 | 0.46 |
| ▸ | PARP1 | P09874 | 6/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20774424 | 0.89 | MAP3K5 (0.46) | MAP3K5DDB1CRBN | |
| SCHEMBL28607413 | 0.81 | MAP3K5 (0.38) | MAP3K5PARP1PARP10F7F3 | |
| SCHEMBL22473965 | 0.81 | PARP10 (0.41) | MAP3K5PARP1PARP10F7F3 | |
| SCHEMBL21750535 | 0.80 | MAP3K5 (0.38) | MAP3K5DDB1CRBN | |
| SCHEMBL20489212 | 0.80 | MAP3K5 (0.49) | MAP3K5PARP1PARP10PARP11 | |
| SCHEMBL29978642 | 0.80 | MAP3K5 (0.49) | MAP3K5PARP1PARP10PARP11 | |
| SCHEMBL28941273 | 0.80 | PARP10 (0.40) | MAP3K5PARP1PARP10F7F3 | |
| SCHEMBL28887761 | 0.80 | PARP10 (0.40) | MAP3K5PARP1PARP10F7F3 | |
| SCHEMBL30362996 | 0.80 | PARP10 (0.40) | MAP3K5PARP1PARP10F7F3 | |
| SCHEMBL30362908 | 0.79 | GRM5 (0.38) | MAP3K5PARP10PARP11DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110294742-B | Fused ring ASK1 inhibitor and application thereof | 山东轩竹医药科技有限公司 | 2023-01-31 | — | — | CN | disclosed |
| EP-3572401-B1 | ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | FUJIAN COSUNTER PHARMACEUTICAL CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |