Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 17/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20489212 | 1.00 | MAP3K5 (0.49) | MAP3K5PARP10PARP11PARP1KDM4E | |
| SCHEMBL21705962 | 0.89 | MAP3K5 (0.47) | MAP3K5 | |
| SCHEMBL28607413 | 0.87 | MAP3K5 (0.38) | MAP3K5PARP10PARP11PARP1KDM4E | |
| SCHEMBL22473965 | 0.87 | PARP10 (0.41) | MAP3K5PARP10PARP11PARP1KDM4E | |
| SCHEMBL30362996 | 0.86 | PARP10 (0.40) | MAP3K5PARP10PARP11PARP1KDM4E | |
| SCHEMBL28941273 | 0.86 | PARP10 (0.40) | MAP3K5PARP10PARP11PARP1KDM4E | |
| SCHEMBL28887761 | 0.86 | PARP10 (0.40) | MAP3K5PARP10PARP11PARP1KDM4E | |
| SCHEMBL28910942 | 0.84 | MAP3K5 (0.39) | MAP3K5PARP10PARP11PARP1KDM4E | |
| SCHEMBL28533456 | 0.80 | MAP3K5 (0.36) | MAP3K5PARP10PARP11PARP1KDM4E | |
| SCHEMBL28539135 | 0.80 | MAP3K5 (0.38) | MAP3K5PARP10PARP11PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115504986-B | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-115504986-A | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-111094250-B | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-11-04 | — | — | CN | disclosed |