Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 6/20 | 0.49 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 5/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TET3 | O43151 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | FBXL19 | Q6PCT2 | 3/20 | 0.38 |
| ▸ | CXXC5 | Q7LFL8 | 3/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.38 |
| ▸ | CXXC4 | Q9H2H0 | 3/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.38 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | BMX | P51813 | 1/20 | 0.34 |
| ▸ | CD69 | Q07108 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4578425 | 0.82 | TEAD1 (0.50) | TEAD1TEAD3JAK3JAK2JAK1 | |
| SCHEMBL4578429 | 0.82 | TEAD1 (0.50) | TEAD1TEAD3JAK3JAK2JAK1 | |
| SCHEMBL16671735 | 0.81 | TEAD1 (0.49) | TEAD1TEAD3JAK3JAK2JAK1 | |
| SCHEMBL17085551 | 0.81 | TEAD1 (0.49) | TEAD1TEAD3JAK3JAK2JAK1 | |
| SCHEMBL16030874 | 0.81 | TEAD1 (0.56) | TEAD1TEAD3JAK3JAK2JAK1 | |
| SCHEMBL18333367 | 0.79 | TEAD1 (0.55) | TEAD1TEAD3JAK3JAK2JAK1 | |
| SCHEMBL20839679 | 0.79 | TEAD1 (0.51) | TEAD1TEAD3JAK3JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL25281152 | 0.79 | TEAD1 (0.48) | TEAD1TEAD3JAK3JAK2JAK1 | |
| SCHEMBL16285090 | 0.78 | TEAD1 (0.47) | TEAD1TEAD3JAK3JAK2JAK1 | |
| SCHEMBL18328751 | 0.78 | TEAD1 (0.54) | TEAD1TEAD3JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |