Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | POLR1A | O95602 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | IL1B | P01584 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22519390 | 1.00 | MALT1 (0.43) | MALT1POLR1AALDH1A1TSHRDPP4 | |
| SCHEMBL30741404 | 0.83 | MALT1 (0.46) | MALT1POLR1AALDH1A1TSHRIL1B | |
| SCHEMBL23866592 | 0.83 | MALT1 (0.46) | MALT1POLR1AALDH1A1TSHRIL1B | |
| SCHEMBL23866634 | 0.82 | CACNA1H (0.36) | MALT1POLR1AALDH1A1TSHRIL1B | |
| SCHEMBL28650867 | 0.80 | MALT1 (0.44) | MALT1POLR1AALDH1A1IL1BP2RX7 | |
| SCHEMBL16791399 | 0.78 | MALT1 (0.43) | MALT1POLR1AALDH1A1TSHRIL1B | |
| SCHEMBL23866583 | 0.76 | DPP4 (0.48) | MALT1ALDH1A1DPP4PREPFAP | |
| SCHEMBL12413667 | 0.76 | DPP4 (0.48) | MALT1ALDH1A1DPP4PREPFAP | |
| SCHEMBL18233614 | 0.76 | MALT1 (0.35) | MALT1POLR1AIL1BP2RX7HTR3A | |
| SCHEMBL13115966 | 0.75 | DPP4 (0.43) | MALT1DPP4PREPFAPHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | MALT1 505/4885POLR1A 1057/4885ALDH1A1 2764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.