Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21527256 | 0.81 | TSHR (0.39) | HCAR2TSHR | |
| SCHEMBL20232414 | 0.81 | IRAK4 (0.31) | IRAK4 | |
| SCHEMBL24567762 | 0.80 | TSHR (0.34) | TSHRALDH2IRAK4 | |
| SCHEMBL24456537 | 0.80 | TSHR (0.34) | TSHRALDH2IRAK4 | |
| SCHEMBL2603220 | 0.80 | TSHR (0.34) | TSHRALDH2IRAK4 | |
| SCHEMBL26733562 | 0.77 | TLR8 (0.33) | TSHR | |
| SCHEMBL21494786 | 0.77 | TSHR (0.33) | CYP3A4TSHRIRAK4 | |
| SCHEMBL24512881 | 0.74 | HRH3 (0.35) | — | |
| SCHEMBL21107364 | 0.72 | KDM1A (0.32) | ALDH2 | |
| SCHEMBL4740676 | 0.71 | THRB (0.36) | HCAR2ALDH1A1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195481-A1 | SMALL MOLECULE STAT PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-09-30 | — | — | WO | disclosed |