Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867485 | 0.90 | HCRTR1 (0.46) | HCRTR1HCRTR2LMNAHSD17B10ALDH1A1 | |
| SCHEMBL30234371 | 0.86 | ROCK1 (0.46) | HCRTR1HCRTR2LMNAHSD17B10ALDH1A1 | |
| SCHEMBL31094227 | 0.85 | SLC2A1 (0.44) | SLC2A1LMNAHSD17B10ALDH1A1KDM4E | |
| SCHEMBL23867468 | 0.83 | HRH3 (0.45) | HCRTR1HCRTR2SLC2A1LMNAHSD17B10 | |
| SCHEMBL23867470 | 0.82 | HRH3 (0.44) | HCRTR1HCRTR2SLC2A1LMNAHSD17B10 | |
| SCHEMBL30234700 | 0.82 | HRH3 (0.47) | SLC2A1LMNAHSD17B10ALDH1A1KDM4E | |
| SCHEMBL23867472 | 0.81 | HRH3 (0.48) | HCRTR1HCRTR2SLC2A1LMNAHSD17B10 | |
| SCHEMBL23867490 | 0.81 | HRH3 (0.42) | HCRTR1HCRTR2SLC2A1LMNAALDH1A1 | |
| SCHEMBL23867473 | 0.81 | HCRTR1 (0.53) | HCRTR1HCRTR2SLC2A1KDM4EHPGD | |
| SCHEMBL30979651 | 0.80 | SLC2A1 (0.51) | HCRTR1HCRTR2SLC2A1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023055763-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTRAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2023-04-06 | — | — | WO | disclosed |
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |