SCHEMBL23868147

SCHEMBL23868147

C=CCC[C@H]1COc2cc(C(N)=O)cc3nc(NC(=O)c4cc(C)nn4CC4CC4)n1c23

nearest known ligand 0.47

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
STING1 Q86WV6 20/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23855727 0.93 STING1 (0.48) STING1
SCHEMBL23868212 0.90 STING1 (0.49) STING1
SCHEMBL23855722 0.86 STING1 (0.40) STING1
SCHEMBL21766173 0.86 STING1 (0.48) STING1
SCHEMBL23855774 0.85 STING1 (0.43) STING1
SCHEMBL23855775 0.85 STING1 (0.43) STING1
SCHEMBL21789991 0.85 STING1 (0.58) STING1
SCHEMBL23855757 0.84 STING1 (0.58) STING1
SCHEMBL22109969 0.84 STING1 (0.58) STING1
SCHEMBL21766221 0.83 STING1 (0.55) STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11535633-B2 Fused tricyclic heterocycle compounds and therapeutic uses thereof JIANGSU HENGRUI MEDICINE CO., LTD. (CN) 2022-12-27 US disclosed
US-20210300944-A1 FUSED TRICYCLIC HETEROCYCLE COMPOUNDS AND THERAPEUTIC USES THEREOF JIANGSU HENGRUI MEDICINE CO., LTD. (CN) 2021-09-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11535633-B2 Fused tricyclic heterocycle compounds and therapeutic uses thereof STING1, CGAS, MAVS STING1 1/4885
US-20210300944-A1 FUSED TRICYCLIC HETEROCYCLE COMPOUNDS AND THERAPEUTIC USES THEREOF STING1, CGAS, MAVS STING1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.