Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | TOP1 | P11387 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17451948 | 0.84 | TOP1 (0.46) | PARP1TOP1MEN1KMT2ARAB9A | |
| SCHEMBL17403775 | 0.83 | PARP1 (0.46) | PARP1TOP1MEN1KMT2ARAB9A | |
| SCHEMBL14020765 | 0.83 | PARP1 (0.47) | PARP1TOP1MEN1KMT2ARAB9A | |
| SCHEMBL11991106 | 0.82 | NPSR1 (0.40) | PARP1TOP1MEN1KMT2ANPSR1 | |
| SCHEMBL17174105 | 0.81 | PARP1 (0.46) | PARP1TOP1MEN1KMT2ARAB9A | |
| SCHEMBL17174127 | 0.81 | PARP1 (0.46) | PARP1TOP1MEN1KMT2ARAB9A | |
| SCHEMBL20108851 | 0.81 | PARP1 (0.44) | PARP1TOP1MEN1KMT2ARAB9A | |
| SCHEMBL20108871 | 0.80 | TOP1 (0.41) | PARP1TOP1MEN1KMT2ARAB9A | |
| SCHEMBL11991067 | 0.80 | TOP1 (0.44) | TOP1MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL17451977 | 0.79 | TOP1 (0.44) | PARP1TOP1PIM1PIM2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076524-B1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2016-04-20 | — | — | EP | disclosed |
| EP-2076524-B1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2016-04-20 | — | — | EP | disclosed |
| US-8735583-B2 | Chiral phosphorus compound | JOHNSON MATTHEY PUBLIC LIMITED CO. (GB) | 2014-05-27 | — | — | US | disclosed |
| US-8735583-B2 | Chiral phosphorus compound | JOHNSON MATTHEY PUBLIC LIMITED CO. (GB) | 2014-05-27 | — | — | US | disclosed |
| US-8735583-B2 | Chiral phosphorus compound | JOHNSON MATTHEY PUBLIC LIMITED CO. (GB) | 2014-05-27 | — | — | US | disclosed |
| US-20130150583-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2013-06-13 | — | — | US | disclosed |
| US-20130150583-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2013-06-13 | — | — | US | disclosed |
| US-20130150583-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2013-06-13 | — | — | US | disclosed |
| US-8404843-B2 | Chiral phosphorus compound | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2013-03-26 | — | — | US | disclosed |
| US-20120264940-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2012-10-18 | — | — | US | disclosed |
| US-8222415-B2 | Chiral phosphorus compound | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2012-07-17 | — | — | US | disclosed |
| US-20120004411-A9 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2012-01-05 | — | — | US | disclosed |
| US-20120004411-A9 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2012-01-05 | — | — | US | disclosed |
| US-20120004411-A9 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2012-01-05 | — | — | US | disclosed |
| US-20100240898-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2010-09-23 | — | — | US | disclosed |
| US-20100240898-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2010-09-23 | — | — | US | disclosed |
| US-20100240898-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2010-09-23 | — | — | US | disclosed |
| EP-2076524-A1 | CHIRAL PHOSPHORUS COMPOUND | Johnson Matthey Public Limited Company (GB) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008041029-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008041029-A1 | CHIRAL PHOSPHORUS COMPOUND | JOHNSON MATTHEY PLC (GB) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264940-A1 | CHIRAL PHOSPHORUS COMPOUND | PIK3CA, RECQL, P2RY1 | PARP1 495/4885TOP1 528/4885MEN1 922/4885 |
| US-20120004411-A9 | CHIRAL PHOSPHORUS COMPOUND | PIK3CA, RECQL, P2RY1 | PARP1 495/4885TOP1 528/4885MEN1 922/4885 |
| US-20100240898-A1 | CHIRAL PHOSPHORUS COMPOUND | PIK3CA, RECQL, P2RY1 | PARP1 495/4885TOP1 528/4885MEN1 922/4885 |
| US-20130150583-A1 | CHIRAL PHOSPHORUS COMPOUND | ALPP, PTH1R, CALCR | PARP1 2019/4885TOP1 1602/4885MEN1 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.