ALPP — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL18426397	0.65	1/20
SCHEMBL3587930	0.60	1/20
SCHEMBL5252741	0.59	1/20
SCHEMBL12495433	0.56	1/20
SCHEMBL12497263	0.56	1/20
SCHEMBL15360160	0.56	1/20
SCHEMBL8568782	0.54	1/20
SCHEMBL30951936	0.53	1/20
SCHEMBL14470429	0.50	1/20
SCHEMBL1802569	0.49	1/20
SCHEMBL5000985	0.49	1/20
SCHEMBL3472014	0.49	1/20
SCHEMBL22110373	0.47	1/20
SCHEMBL26079026	0.47	1/20
SCHEMBL484344	0.47	1/20
SCHEMBL29427371	0.47	1/20
SCHEMBL26817834	0.46	1/20
SCHEMBL23196653	0.46	1/20
SCHEMBL26817974	0.45	1/20
SCHEMBL30874938	0.45	1/20

Clinical trials — most relevant to ALPP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of IPTp-DP Versus IPTp-SP in Malawi	PHASE3	COMPLETED
Sodium Valproate for GSDV	PHASE2	COMPLETED
Vitamin D Dose-Response Study to Establish Dietary Requirements in Infants	PHASE2	COMPLETED
Effect of Progesterone on Latent Phase Prolongation in Patients With Preterm Premature Rupture of Membranes	PHASE2	COMPLETED
Selinexor Treatment for Multiple Myeloma Patients Who Are Refractory to Lenalidomide-containing Therapy.	PHASE1	UNKNOWN
The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome	nan	RECRUITING
Effect Of Scaling and Root Planning on ALP in Saliva and GCF In Periodontitis Patients Compared With Healthy Individuals	nan	UNKNOWN
Search Elevated Serum Alkaline Phosphatase as a Marker of Prenatal Intervillositis Chronic Histiocytic	nan	COMPLETED
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics)	nan	COMPLETED
Biomarker for Hypophosphatasia Disease (BioHypophos)	nan	WITHDRAWN
Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight	nan	COMPLETED
The Effect of Monoallelic Variants in the ALPL Gene on the Natural Course of Hypophosphatasia in Russia	nan	RECRUITING
Serum Alkaline Phosphatase Levels In Healthy Turkish Children	nan	COMPLETED
EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE)	nan	RECRUITING
Placental Volume Analysis During Pregnanay	nan	UNKNOWN
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population	nan	RECRUITING
Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia	nan	UNKNOWN
Natural History Study of Patients With Hypophosphatasia (HPP)	nan	RECRUITING
Bone Metabolism and Parathyroid Hormone-related Protein (PTHrP) Lactation Study	nan	COMPLETED
Evaluation of Sickle Cell Liver Disease	nan	COMPLETED
African-American Bone Metabolism and Lactation Study	nan	COMPLETED
Planetary Habitat Simulation: Bone Metabolism Studies	nan	COMPLETED
Vitamin D Status and Metabolism in Human Pregnancy	nan	COMPLETED
A Cohort of Maternal Vascular Malperfusion-related FGR (CoMVMFGR)	nan	RECRUITING
Transcriptome Profiling and Endometrial Receptivity	nan	RECRUITING
Inhaled Fluticasone Propionate: Effect on Parameters of Bone Metabolism in Patients With Mild to Moderate Asthma	nan	WITHDRAWN
Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus	nan	COMPLETED
Mineral Status in Pregnant Women	nan	RECRUITING
Characteristics of Hypophosphatasia in Adult Patients in Rheumatology	nan	UNKNOWN
Descriptive Study of the Incidence and Outcome of PAS in Two Large Referral Hospitals in Egypt	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ALPP binder may also engage these)

Protein	Name	Similarity
ALPG	Alkaline phosphatase, germ cell type	1.000	landscape →
P24822	—	0.997	P24822 →
P15693	—	0.993	P15693 →
P24823	—	0.993	P24823 →
P19111	—	0.992	P19111 →
ALPI	Intestinal-type alkaline phosphatase	0.987	landscape →
Q92058	—	0.987	Q92058 →
ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.979	landscape →
P09242	—	0.973	P09242 →
P08289	—	0.970	P08289 →
P51740	—	0.970	P51740 →
P83456	—	0.966	P83456 →
Q29486	—	0.964	Q29486 →
P09487	—	0.963	P09487 →
P15848	—	0.957	P15848 →
O46432	—	0.954	O46432 →
P33727	—	0.953	P33727 →
Q6UWV6	—	0.953	Q6UWV6 →
P58242	—	0.952	P58242 →
P50429	—	0.951	P50429 →
P50430	—	0.948	P50430 →
Q04519	—	0.946	Q04519 →
FUCA2	Plasma alpha-L-fucosidase	0.946	landscape →
P53761	—	0.945	P53761 →
Q2KHZ8	—	0.945	Q2KHZ8 →
Q8NCC3	—	0.945	Q8NCC3 →
O89023	—	0.945	O89023 →
B6EWW8	—	0.944	B6EWW8 →
Q8VHC8	—	0.944	Q8VHC8 →
Q92485	—	0.944	Q92485 →