Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23794083 | 1.00 | GRIN1 (0.37) | GRIN1GRIN2ABRD4BRD2EHMT2 | |
| SCHEMBL23869808 | 1.00 | GRIN1 (0.37) | GRIN1GRIN2ABRD4BRD2EHMT2 | |
| SCHEMBL23869994 | 0.88 | GRIN1 (0.33) | GRIN1GRIN2A | |
| SCHEMBL22744626 | 0.88 | GRIN1 (0.33) | GRIN1GRIN2A | |
| SCHEMBL23869974 | 0.88 | GRIN1 (0.33) | GRIN1GRIN2A | |
| SCHEMBL19174271 | 0.74 | GRIN1 (0.40) | GRIN1GRIN2ABRD4BRD2EHMT2 | |
| SCHEMBL23168692 | 0.74 | GRIN1 (0.40) | GRIN1GRIN2ABRD4BRD2EHMT2 | |
| SCHEMBL25900548 | 0.70 | GRIN1 (0.36) | GRIN1GRIN2ABRD4BRD2 | |
| SCHEMBL23794163 | 0.69 | GRIN1 (0.37) | GRIN1GRIN2ABRD4BRD2EHMT2 | |
| SCHEMBL25913911 | 0.69 | GRIN1 (0.37) | GRIN1GRIN2ABRD4BRD2EHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827634-B2 | Small molecule inhibitors of NF-kB inducing kinase | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-28 | — | — | US | disclosed |
| US-11827634-B2 | Small molecule inhibitors of NF-kB inducing kinase | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-28 | — | — | US | disclosed |
| US-11254673-B2 | Small molecule inhibitors of NF-κB inducing kinase | JANSSEN PHARMACEUTICA NV (BE) | 2022-02-22 | — | — | US | disclosed |
| US-20210300918-A1 | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300918-A1 | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE | NFKBIA, IKBKB, NFRKB | GRIN1 4394/4885GRIN2A 4803/4885BRD4 597/4885 |
| US-11827634-B2 | Small molecule inhibitors of NF-kB inducing kinase | NFKBIA, IKBKB, NFRKB | GRIN1 4394/4885GRIN2A 4803/4885BRD4 597/4885 |
| US-11254673-B2 | Small molecule inhibitors of NF-κB inducing kinase | NFKBIA, IKBKB, CHUK | GRIN1 4309/4885GRIN2A 4795/4885BRD4 481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.