Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28037304 | 1.00 | PPM1D (0.34) | PPM1D | |
| SCHEMBL139881 | 0.87 | PPM1D (0.35) | PPM1D | |
| SCHEMBL2386709 | 0.87 | PPM1D (0.35) | PPM1D | |
| SCHEMBL142690 | 0.87 | PPM1D (0.35) | PPM1D | |
| SCHEMBL2081002 | 0.85 | PPM1D (0.32) | PPM1D | |
| SCHEMBL3955174 | 0.83 | HCRTR1 (0.35) | — | |
| SCHEMBL2080407 | 0.82 | PPM1D (0.33) | PPM1D | |
| SCHEMBL18394294 | 0.82 | PPM1D (0.33) | PPM1D | |
| SCHEMBL140873 | 0.82 | PPM1D (0.33) | PPM1D | |
| SCHEMBL16538825 | 0.82 | PPM1D (0.33) | PPM1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105037367-A | Amino six-membered ring derivative and application thereof in medicines | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2015-11-11 | — | — | CN | disclosed |
| US-8017611-B2 | Pyridine and pyrazine derivatives -083 | ASTRAZENECA AB (SE) | 2011-09-13 | — | — | US | disclosed |
| EP-2215085-B1 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-09-07 | — | — | EP | disclosed |