Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 4/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20333513 | 0.81 | PIK3CD (0.41) | SCN1ASCN5ASCN8ASMN1; SMN2HTT | |
| SCHEMBL14080696 | 0.77 | HSP90AA1 (0.40) | SCN1ASCN5ASCN8ASMN1; SMN2HTT | |
| SCHEMBL23308873 | 0.77 | SCN1A (0.38) | SCN1ASCN5ASCN8ASMN1; SMN2HTT | |
| SCHEMBL20330202 | 0.76 | SCN1A (0.43) | SCN1ASCN5ASCN8ASMN1; SMN2HTT | |
| SCHEMBL21790175 | 0.76 | SCN1A (0.38) | SCN1ASCN5ASCN8ASMN1; SMN2HTT | |
| SCHEMBL6320584 | 0.76 | KDM4E (0.61) | HPGDSMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL21307084 | 0.74 | SCN1A (0.37) | SCN1ASCN5ASCN8ASMN1; SMN2HTT | |
| SCHEMBL22984858 | 0.73 | SCN9A (0.37) | SCN1ASCN5ASCN8ASMN1; SMN2HTT | |
| SCHEMBL18843940 | 0.73 | SCN9A (0.54) | SMN1; SMN2HTTCYP2C19KDM4EALDH1A1 | |
| SCHEMBL21755120 | 0.72 | HPGD (0.73) | HPGDMAPTL3MBTL1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300934-A1 | MACROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS, INC. | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300934-A1 | MACROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS | CFD, TFPI, CFH | HPGD 115/4885MAPT 3729/4885L3MBTL1 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.