Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26972296 | 0.84 | GRM1 (0.47) | KDM4EALDH1A1MAPTHSD11B1GRM1 | |
| SCHEMBL26972293 | 0.84 | GRM1 (0.47) | KDM4EALDH1A1MAPTHSD11B1GRM1 | |
| SCHEMBL22837869 | 0.81 | HSD11B1 (0.50) | KDM4EALDH1A1MAPTHSD11B1GRM1 | |
| SCHEMBL23875206 | 0.81 | HSD11B1 (0.50) | KDM4EALDH1A1MAPTHSD11B1GRM1 | |
| SCHEMBL23875353 | 0.79 | PLD1 (0.52) | KDM4EALDH1A1MAPTHSD11B1GRM1 | |
| SCHEMBL23875159 | 0.78 | GRIN1 (0.43) | ALDH1A1DRD4GRIN2B | |
| SCHEMBL23875161 | 0.78 | GRIN1 (0.43) | ALDH1A1DRD4GRIN2B | |
| SCHEMBL28768958 | 0.76 | HSD11B1 (0.49) | KDM4EALDH1A1MAPTHSD11B1GRM1 | |
| SCHEMBL28768957 | 0.76 | HSD11B1 (0.62) | KDM4EALDH1A1HSD11B1GRM1GRIN2B | |
| SCHEMBL29991351 | 0.76 | GRIN2B (0.49) | KDM4EALDH1A1MAPTHSD11B1GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021194878-A1 | SELECTIVE MODULATORS OF MUTANT LRRK2 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-09-30 | — | — | WO | disclosed |