Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 4/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11281707 | 0.83 | ESR1 (0.46) | ESR1SMN1; SMN2KDM4EALDH1A1CXCR2 | |
| SCHEMBL23275208 | 0.82 | ESR1 (0.45) | ESR1SMN1; SMN2KDM4EALDH1A1CXCR2 | |
| SCHEMBL29762427 | 0.82 | ESR1 (0.45) | ESR1SMN1; SMN2KDM4EALDH1A1CXCR2 | |
| SCHEMBL23275205 | 0.82 | ESR1 (0.45) | ESR1SMN1; SMN2KDM4EALDH1A1CXCR2 | |
| SCHEMBL16094689 | 0.81 | ESR1 (0.61) | ESR1SMN1; SMN2KDM4EALDH1A1CXCR2 | |
| SCHEMBL16094691 | 0.81 | ESR1 (0.61) | ESR1SMN1; SMN2KDM4EALDH1A1CXCR2 | |
| SCHEMBL16454931 | 0.77 | PGK1 (0.38) | ESR1NOS2CYP2D6CYP2C19S1PR2 | |
| SCHEMBL23299899 | 0.76 | CYP2D6 (0.60) | SMN1; SMN2KDM4EALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL28623660 | 0.75 | ESR1 (0.44) | ESR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL28623661 | 0.75 | ESR1 (0.44) | ESR1SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300904-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300904-A1 | INHIBITORS OF RAF KINASES | BRAF, RAF1, ARAF | ESR1 2072/4885SMN1; SMN2 3700/4885KDM4E 1831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.