Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 3/20 | 0.50 |
| ▸ | PAK4 | O96013 | 3/20 | 0.50 |
| ▸ | TYK2 | P29597 | 15/20 | 0.44 |
| ▸ | JAK3 | P52333 | 15/20 | 0.44 |
| ▸ | JAK2 | O60674 | 10/20 | 0.44 |
| ▸ | JAK1 | P23458 | 10/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.44 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23889714 | 0.86 | PLK4 (0.51) | PLK4PAK4TYK2JAK3JAK2 | |
| SCHEMBL23889443 | 0.83 | JAK3 (0.49) | PLK4PAK4TYK2JAK3JAK2 | |
| SCHEMBL23878910 | 0.81 | TYK2 (0.57) | PLK4PAK4TYK2JAK3JAK2 | |
| SCHEMBL22055022 | 0.78 | TYK2 (0.71) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL23879148 | 0.78 | TYK2 (0.71) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL24995640 | 0.78 | TYK2 (0.71) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL30227628 | 0.77 | TYK2 (0.53) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL22054128 | 0.77 | TYK2 (0.53) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL12430651 | 0.76 | AURKA (0.68) | PLK4PAK4AURKASRCGSK3B | |
| SCHEMBL10267511 | 0.76 | AURKA (0.53) | PLK4PAK4AURKASRCGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889152-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |