Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.44 |
| ▸ | TYK2 | P29597 | 10/20 | 0.44 |
| ▸ | JAK2 | O60674 | 10/20 | 0.44 |
| ▸ | JAK1 | P23458 | 10/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 4/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | PAK4 | O96013 | 2/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23878837 | 0.96 | JAK1 (0.47) | JAK3TYK2JAK2JAK1GPR119 | |
| SCHEMBL30147244 | 0.96 | JAK1 (0.47) | JAK3TYK2JAK2JAK1GPR119 | |
| SCHEMBL22054234 | 0.96 | JAK1 (0.47) | JAK3TYK2JAK2JAK1GPR119 | |
| SCHEMBL23878809 | 0.95 | GPR119 (0.47) | JAK3TYK2JAK2JAK1GPR119 | |
| SCHEMBL22054224 | 0.95 | GPR119 (0.47) | JAK3TYK2JAK2JAK1GPR119 | |
| SCHEMBL23889629 | 0.87 | JAK1 (0.47) | JAK3TYK2JAK2JAK1GPR119 | |
| SCHEMBL22054226 | 0.87 | JAK1 (0.47) | JAK3TYK2JAK2JAK1GPR119 | |
| SCHEMBL30147222 | 0.87 | JAK1 (0.47) | JAK3TYK2JAK2JAK1GPR119 | |
| SCHEMBL23879004 | 0.85 | TYK2 (0.47) | JAK3TYK2JAK2JAK1BRD4 | |
| SCHEMBL30147242 | 0.85 | TYK2 (0.48) | JAK3TYK2JAK2JAK1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889152-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |