Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.66 |
| ▸ | TYK2 | P29597 | 7/20 | 0.66 |
| ▸ | JAK3 | P52333 | 7/20 | 0.66 |
| ▸ | JAK1 | P23458 | 6/20 | 0.66 |
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23879140 | 1.00 | JAK2 (0.66) | JAK2TYK2JAK3JAK1AURKA | |
| SCHEMBL22054021 | 1.00 | JAK2 (0.66) | JAK2TYK2JAK3JAK1AURKA | |
| SCHEMBL22054006 | 0.90 | TYK2 (0.60) | JAK2TYK2JAK3JAK1AURKA | |
| SCHEMBL22054221 | 0.90 | JAK2 (0.55) | JAK2TYK2JAK3JAK1AURKA | |
| SCHEMBL23878992 | 0.89 | AURKA (0.59) | JAK2TYK2JAK3JAK1AURKA | |
| SCHEMBL30255661 | 0.88 | AURKA (0.58) | JAK2TYK2JAK3JAK1AURKA | |
| SCHEMBL24995303 | 0.86 | TYK2 (0.57) | JAK2TYK2JAK3JAK1AURKA | |
| SCHEMBL22055383 | 0.86 | JAK2 (0.57) | JAK2TYK2JAK3JAK1 | |
| SCHEMBL23878951 | 0.86 | TYK2 (0.57) | JAK2TYK2JAK3JAK1GSK3B | |
| SCHEMBL23879060 | 0.86 | JAK2 (0.57) | JAK2TYK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889152-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |