Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 10/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12915119 | 0.81 | CYP2A6 (0.56) | CYP2A6CYP3A4CYP2E1CYP2D6CYP2C9 | |
| SCHEMBL30546895 | 0.80 | CYP2A6 (0.50) | CYP2A6CYP3A4CYP2E1CYP2D6CYP2C9 | |
| SCHEMBL29248879 | 0.80 | CYP2A6 (0.50) | CYP2A6CYP3A4CYP2E1CYP2D6CYP2C9 | |
| SCHEMBL5511611 | 0.79 | CYP2A6 (0.49) | CYP2A6CYP3A4CYP2E1CYP2D6CYP2C9 | |
| SCHEMBL29248875 | 0.79 | CYP2A6 (0.49) | CYP2A6CYP3A4CYP2E1CYP2D6CYP2C9 | |
| SCHEMBL19961427 | 0.77 | CYP2A6 (0.56) | CYP2A6CYP3A4CYP2E1CYP2D6CYP2C9 | |
| SCHEMBL334755 | 0.77 | CYP2A6 (0.56) | CYP2A6CYP3A4CYP2E1CYP2D6CYP2C9 | |
| SCHEMBL22272472 | 0.76 | CYP2A6 (0.46) | CYP2A6CYP3A4CYP2E1CYP2D6CYP2C9 | |
| SCHEMBL14803290 | 0.76 | CYP2A6 (0.46) | CYP2A6CYP3A4CYP2E1CYP2D6CYP2C9 | |
| SCHEMBL22351934 | 0.74 | CYP2A6 (0.51) | CYP2A6CYP3A4CYP2E1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3528808-B1 | METHODS OF USING INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS | BIOSPLICE THERAPEUTICS INC (US) | 2021-10-06 | — | — | EP | disclosed |