Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22799749 | 0.83 | EPHX1 (0.51) | CYP2A6CYP3A4CYP2E1CYP2C9CYP2B6 | |
| SCHEMBL12915119 | 0.79 | CYP2A6 (0.56) | CYP2A6CYP3A4CYP2E1CYP2C9CYP2B6 | |
| SCHEMBL9285273 | 0.77 | KCNA5 (0.59) | CYP2A6CYP3A4CYP2E1CYP2C9CYP2B6 | |
| SCHEMBL29248879 | 0.77 | CYP2A6 (0.50) | CYP2A6CYP3A4CYP2E1CYP2C9CYP2B6 | |
| SCHEMBL30546895 | 0.77 | CYP2A6 (0.50) | CYP2A6CYP3A4CYP2E1CYP2C9CYP2B6 | |
| SCHEMBL23889758 | 0.76 | CYP2A6 (0.49) | CYP2A6CYP3A4CYP2E1CYP2C9CYP2B6 | |
| SCHEMBL5511611 | 0.76 | CYP2A6 (0.49) | CYP2A6CYP3A4CYP2E1CYP2C9CYP2B6 | |
| SCHEMBL29248875 | 0.76 | CYP2A6 (0.49) | CYP2A6CYP3A4CYP2E1CYP2C9CYP2B6 | |
| SCHEMBL14803290 | 0.73 | CYP2A6 (0.46) | CYP2A6CYP3A4CYP2E1CYP2C9CYP2B6 | |
| SCHEMBL11074941 | 0.73 | PDCD1 (0.69) | CYP2A6CYP3A4CYP2E1CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780823-B2 | Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-20230047396-A1 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2023-02-16 | — | — | US | disclosed |
| US-11066388-B2 | Indazole-3-carboxamides and their use as WNT/B-catenin signaling pathway inhibitors | BIOSPLICE THERAPEUTICS, INC. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200239436-A1 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047396-A1 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS | WNT1, WNT3, WNT3A | CYP2A6 2157/4885CYP3A4 1712/4885CYP2E1 1627/4885 |
| US-20200239436-A1 | INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS | WNT1, WNT3, WNT3A | CYP2A6 2157/4885CYP3A4 1712/4885CYP2E1 1627/4885 |
| US-11066388-B2 | Indazole-3-carboxamides and their use as WNT/B-catenin signaling pathway inhibitors | WNT1, WNT3, WNT3A | CYP2A6 2157/4885CYP3A4 1712/4885CYP2E1 1627/4885 |
| US-11780823-B2 | Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors | WNT1, WNT3, WNT3A | CYP2A6 2336/4885CYP3A4 1684/4885CYP2E1 1571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.