Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3328962 | 0.82 | MEN1 (1.00) | MEN1KMT2AHTR2AKDM4EPDCD1LG2 | |
| SCHEMBL16610538 | 0.82 | MEN1 (0.73) | MEN1KMT2AHTR2APDCD1LG2CD274 | |
| SCHEMBL22040843 | 0.81 | MEN1 (0.71) | MEN1KMT2AHTR2APDCD1LG2CD274 | |
| SCHEMBL29209276 | 0.78 | TRPA1 (0.44) | MEN1KMT2A | |
| SCHEMBL19580279 | 0.77 | MEN1 (0.66) | MEN1KMT2AHTR2APDCD1LG2CD274 | |
| SCHEMBL31472389 | 0.77 | MEN1 (0.89) | MEN1KMT2AKDM4E | |
| SCHEMBL21491464 | 0.77 | MEN1 (0.89) | MEN1KMT2AKDM4E | |
| SCHEMBL469013 | 0.76 | MEN1 (0.65) | MEN1KMT2APDCD1LG2CD274CHRNB4 | |
| SCHEMBL29589447 | 0.76 | MEN1 (0.65) | MEN1KMT2APDCD1LG2CD274CHRNB4 | |
| SCHEMBL23323077 | 0.76 | MEN1 (0.65) | MEN1KMT2APDCD1LG2CD274CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177611-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2021-10-06 | — | — | EP | disclosed |