Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286104 | 0.83 | PDE2A (0.43) | PDE2ASIGMAR1LMNAHTR2ASLC6A4 | |
| SCHEMBL10087177 | 0.81 | PDE2A (0.46) | PDE2AALDH1A1GPR139KCNA5EEF2K | |
| SCHEMBL13376374 | 0.81 | PDE2A (0.42) | PDE2AALDH1A1GPR139KCNA5EEF2K | |
| SCHEMBL8298546 | 0.81 | PDE2A (0.42) | PDE2AALDH1A1GPR139KCNA5EEF2K | |
| SCHEMBL28220660 | 0.80 | HTR2A (0.54) | SIGMAR1LMNAMAPTADRA2CHTR2A | |
| SCHEMBL12154076 | 0.79 | PDE2A (0.47) | PDE2ASIGMAR1LMNAMAPTADRA2C | |
| SCHEMBL14161448 | 0.79 | PDE2A (0.47) | PDE2ASIGMAR1LMNAMAPTADRA2C | |
| SCHEMBL12154088 | 0.79 | PDE2A (0.47) | PDE2ASIGMAR1LMNAMAPTADRA2C | |
| SCHEMBL22031965 | 0.78 | PDE2A (0.42) | PDE2ASIGMAR1LMNAMAPTADRA2C | |
| SCHEMBL24312242 | 0.78 | PDE2A (0.42) | PDE2ASIGMAR1LMNAMAPTADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177611-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2021-10-06 | — | — | EP | disclosed |