Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.42 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8298546 | 1.00 | PDE2A (0.42) | PDE2AGPR139KCNA5EEF2KCASR | |
| SCHEMBL3595285 | 0.86 | UTS2R (0.42) | PDE2AEEF2KUTS2R | |
| SCHEMBL8286104 | 0.83 | PDE2A (0.43) | PDE2AGPR139KCNA5EEF2KCASR | |
| SCHEMBL23891981 | 0.81 | PDE2A (0.42) | PDE2AGPR139KCNA5EEF2KCASR | |
| SCHEMBL10087177 | 0.81 | PDE2A (0.46) | PDE2AGPR139KCNA5EEF2KCASR | |
| SCHEMBL8046163 | 0.76 | ALDH1A1 (0.51) | GPR139KCNA5ALDH1A1 | |
| SCHEMBL7733495 | 0.76 | GPR139 (0.49) | PDE2AGPR139KCNA5EEF2KUTS2R | |
| SCHEMBL21932831 | 0.75 | PDE2A (0.39) | PDE2AGPR139CASRKIF11FPR2 | |
| SCHEMBL20339684 | 0.75 | KCNK3 (0.41) | — | |
| SCHEMBL30209365 | 0.75 | PDE2A (0.39) | PDE2AGPR139CASRKIF11FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656141-B1 | TREATMENT FOR ALZHEIMER S DISEASE AND RELATED CONDITIONS | MERCK SHARP & DOHME (GB) | 2010-04-14 | — | — | EP | disclosed |