Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.43 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 11/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.40 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.33 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.33 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.33 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130086 | 0.84 | PRMT5 (0.38) | PIP4K2APRMT5WDR77 | |
| SCHEMBL25048531 | 0.83 | YTHDC1 (0.47) | PIP4K2AYTHDC1PRMT5WDR77NAE1 | |
| SCHEMBL10293822 | 0.83 | PIP4K2A (0.49) | PIP4K2AYTHDC1PRMT5WDR77NAE1 | |
| SCHEMBL18571704 | 0.81 | MEN1 (0.41) | PRMT5WDR77 | |
| SCHEMBL23892453 | 0.81 | PIP4K2A (0.39) | PIP4K2APRMT5WDR77UBA6 | |
| SCHEMBL18572230 | 0.81 | PIP4K2A (0.39) | PIP4K2APRMT5WDR77UBA6 | |
| SCHEMBL23892225 | 0.81 | PIP4K2A (0.39) | PIP4K2APRMT5WDR77UBA6 | |
| SCHEMBL25047950 | 0.78 | PRMT5 (0.35) | PIP4K2AYTHDC1PRMT5WDR77NAE1 | |
| SCHEMBL23892515 | 0.75 | PRMT5 (0.44) | PIP4K2AYTHDC1PRMT5WDR77ADORA3 | |
| SCHEMBL25047920 | 0.75 | PIP4K2A (0.39) | PIP4K2AYTHDC1PRMT5WDR77NAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |