Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 8/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 15/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18571957 | 0.93 | PRMT5 (0.54) | METTL3PRMT5WDR77 | |
| SCHEMBL23892259 | 0.92 | PRMT5 (0.48) | METTL3PRMT5WDR77 | |
| SCHEMBL23892550 | 0.89 | METTL3 (0.50) | METTL3PRMT5WDR77 | |
| SCHEMBL24380377 | 0.89 | PRMT5 (0.57) | METTL3PRMT5WDR77 | |
| SCHEMBL18571572 | 0.89 | PRMT5 (0.47) | METTL3PRMT5WDR77 | |
| SCHEMBL18572618 | 0.82 | PRMT5 (0.49) | METTL3PRMT5WDR77 | |
| SCHEMBL18571520 | 0.82 | PRMT5 (0.47) | METTL3PRMT5WDR77 | |
| SCHEMBL18571962 | 0.81 | METTL3 (0.57) | METTL3PRMT5WDR77 | |
| SCHEMBL25953408 | 0.80 | PRMT5 (0.56) | METTL3PRMT5WDR77 | |
| SCHEMBL18572209 | 0.80 | PRMT5 (0.59) | METTL3PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |