Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 14/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.43 |
| ▸ | METTL3 | Q86U44 | 7/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892516 | 0.90 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL25951268 | 0.90 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL23892677 | 0.83 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL23892318 | 0.83 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL23892349 | 0.83 | PRMT5 (0.48) | PRMT5WDR77METTL3 | |
| SCHEMBL18572921 | 0.81 | PRMT5 (0.76) | PRMT5WDR77METTL3 | |
| SCHEMBL18572919 | 0.78 | ADK (0.56) | PRMT5WDR77METTL3 | |
| SCHEMBL18572304 | 0.78 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL25046648 | 0.75 | MEN1 (0.44) | PRMT5WDR77METTL3 | |
| SCHEMBL18572307 | 0.75 | PRMT5 (0.44) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |