Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 15/20 | 0.62 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.62 |
| ▸ | METTL3 | Q86U44 | 8/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18572119 | 0.90 | PRMT5 (0.67) | PRMT5WDR77METTL3 | |
| SCHEMBL26829807 | 0.90 | PRMT5 (0.77) | PRMT5WDR77METTL3 | |
| SCHEMBL23892374 | 0.87 | PRMT5 (0.52) | PRMT5WDR77METTL3 | |
| SCHEMBL18572402 | 0.87 | PRMT5 (0.81) | PRMT5WDR77METTL3 | |
| SCHEMBL24380394 | 0.86 | PRMT5 (0.56) | PRMT5WDR77METTL3 | |
| SCHEMBL24595488 | 0.85 | PRMT5 (0.61) | PRMT5WDR77METTL3 | |
| SCHEMBL18572354 | 0.85 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL26829727 | 0.83 | PRMT5 (0.64) | PRMT5WDR77METTL3 | |
| SCHEMBL18572947 | 0.82 | PRMT5 (0.80) | PRMT5WDR77METTL3 | |
| SCHEMBL26571174 | 0.82 | PRMT5 (0.80) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |