Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 15/20 | 0.77 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.77 |
| ▸ | METTL3 | Q86U44 | 8/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26829727 | 0.90 | PRMT5 (0.64) | PRMT5WDR77METTL3 | |
| SCHEMBL23892387 | 0.90 | PRMT5 (0.62) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL29485640 | 0.87 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL22749068 | 0.87 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL29349847 | 0.87 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL25427100 | 0.87 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL22749057 | 0.87 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL25318935 | 0.87 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL22468844 | 0.87 | PRMT5 (1.00) | PRMT5WDR77METTL3 | |
| Onametostat SCHEMBL29352669 | 0.87 | PRMT5 (1.00) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3585904-B1 | USE OF BIOMARKERS IN IDENTIFYING CANCER PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-29 | — | — | EP | disclosed |