Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 8/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 15/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18571908 | 0.92 | METTL3 (0.39) | METTL3PRMT5WDR77PDPK1 | |
| SCHEMBL23892616 | 0.90 | METTL3 (0.36) | METTL3PRMT5WDR77PDPK1 | |
| SCHEMBL23892500 | 0.85 | PRMT5 (0.36) | METTL3PRMT5WDR77PDPK1 | |
| SCHEMBL25951083 | 0.85 | PRMT5 (0.36) | METTL3PRMT5WDR77 | |
| SCHEMBL23892505 | 0.84 | PRMT5 (0.47) | METTL3PRMT5WDR77 | |
| SCHEMBL23892558 | 0.84 | METTL3 (0.40) | METTL3PRMT5WDR77 | |
| SCHEMBL23892285 | 0.83 | PRMT5 (0.38) | METTL3PRMT5WDR77PDPK1 | |
| SCHEMBL23892212 | 0.83 | PRMT5 (0.37) | METTL3PRMT5WDR77PDPK1 | |
| SCHEMBL23892364 | 0.82 | PRMT5 (0.37) | METTL3PRMT5WDR77PDPK1 | |
| SCHEMBL23892556 | 0.82 | PRMT5 (0.37) | METTL3PRMT5WDR77PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |