Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 16/20 | 0.40 |
| ▸ | KDR | P35968 | 11/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 10/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892564 | 0.92 | EPHA2 (0.39) | EPHA2KDREPHB4ERBB2EGFR | |
| SCHEMBL23892623 | 0.92 | EPHA2 (0.39) | EPHA2KDREPHB4ERBB2EGFR | |
| SCHEMBL23892504 | 0.85 | SRC (0.41) | EPHA2KDRENPP1ERBB2EGFR | |
| SCHEMBL23892589 | 0.84 | PRMT5 (0.38) | — | |
| SCHEMBL22683366 | 0.81 | EPHA2 (0.36) | EPHA2KDRENPP1EPHB4ERBB2 | |
| SCHEMBL18571895 | 0.78 | ENPP1 (0.37) | EPHA2KDRENPP1EPHB4ERBB2 | |
| SCHEMBL22002166 | 0.78 | ENPP1 (0.37) | EPHA2KDRENPP1EPHB4ERBB2 | |
| SCHEMBL23892477 | 0.78 | PRMT5 (0.34) | — | |
| SCHEMBL25949786 | 0.78 | PRMT5 (0.40) | — | |
| SCHEMBL25955833 | 0.77 | SRC (0.40) | EPHA2KDRENPP1ERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |