Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 14/20 | 0.39 |
| ▸ | KDR | P35968 | 10/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.39 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892564 | 1.00 | EPHA2 (0.39) | EPHA2KDREPHB4ERBB2PRMT5 | |
| SCHEMBL23892508 | 0.92 | EPHA2 (0.40) | EPHA2KDREPHB4ERBB2EGFR | |
| SCHEMBL25955833 | 0.85 | SRC (0.40) | EPHA2KDRERBB2EGFR | |
| SCHEMBL23892689 | 0.85 | SRC (0.41) | ERBB2PRMT5WDR77METTL3EGFR | |
| SCHEMBL23892344 | 0.85 | PRMT5 (0.48) | PRMT5WDR77METTL3 | |
| SCHEMBL23892565 | 0.85 | PRMT5 (0.48) | PRMT5WDR77METTL3 | |
| SCHEMBL23892641 | 0.84 | PRMT5 (0.47) | PRMT5WDR77METTL3 | |
| SCHEMBL23892699 | 0.82 | PRMT5 (0.49) | PRMT5WDR77METTL3 | |
| SCHEMBL18571824 | 0.81 | PRMT5 (0.59) | PRMT5WDR77METTL3 | |
| SCHEMBL23892467 | 0.79 | PRMT5 (0.49) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |