Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 16/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 9/20 | 0.42 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892337 | 0.87 | PRMT5 (0.58) | PRMT5WDR77METTL3 | |
| SCHEMBL23892346 | 0.86 | METTL3 (0.49) | PRMT5WDR77METTL3 | |
| SCHEMBL23892502 | 0.86 | PRMT5 (0.53) | PRMT5WDR77METTL3 | |
| SCHEMBL23892368 | 0.85 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL23892483 | 0.85 | METTL3 (0.48) | PRMT5WDR77METTL3 | |
| SCHEMBL23892531 | 0.85 | PRMT5 (0.37) | PRMT5WDR77METTL3 | |
| SCHEMBL22002300 | 0.82 | PRMT5 (0.45) | PRMT5WDR77METTL3 | |
| SCHEMBL23892679 | 0.82 | PRMT5 (0.45) | PRMT5WDR77METTL3 | |
| SCHEMBL23892340 | 0.81 | PRMT5 (0.48) | PRMT5WDR77METTL3PIP4K2A | |
| SCHEMBL23892429 | 0.79 | PRMT5 (0.50) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |