Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 11/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 4/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.35 |
| ▸ | NNMT | P40261 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892339 | 0.89 | PRMT5 (0.46) | PRMT5METTL3WDR77 | |
| SCHEMBL18571902 | 0.89 | PRMT5 (0.40) | PRMT5METTL3WDR77NNMT | |
| SCHEMBL23892599 | 0.88 | PRMT5 (0.45) | PRMT5METTL3WDR77 | |
| SCHEMBL23892347 | 0.88 | PRMT5 (0.40) | PRMT5METTL3WDR77 | |
| SCHEMBL23892522 | 0.85 | PRMT5 (0.41) | PRMT5METTL3WDR77 | |
| SCHEMBL18571710 | 0.84 | PRMT5 (0.41) | PRMT5METTL3WDR77 | |
| SCHEMBL23892557 | 0.84 | PRMT5 (0.41) | PRMT5METTL3WDR77 | |
| SCHEMBL23892455 | 0.82 | PRMT5 (0.38) | PRMT5METTL3WDR77 | |
| SCHEMBL23892202 | 0.81 | PRMT5 (0.39) | PRMT5METTL3WDR77 | |
| SCHEMBL23892470 | 0.81 | PRMT5 (0.41) | PRMT5METTL3WDR77EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |