Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 11/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 6/20 | 0.40 |
| ▸ | NNMT | P40261 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25949720 | 0.90 | PRMT5 (0.38) | PRMT5WDR77METTL3 | |
| SCHEMBL23892599 | 0.90 | PRMT5 (0.45) | PRMT5WDR77METTL3KDM4EMAPT | |
| SCHEMBL23892455 | 0.89 | PRMT5 (0.38) | PRMT5WDR77METTL3 | |
| SCHEMBL23892601 | 0.89 | CHRNB2 (0.38) | PRMT5WDR77METTL3NNMT | |
| SCHEMBL23892369 | 0.88 | PRMT5 (0.52) | PRMT5WDR77METTL3 | |
| SCHEMBL18571769 | 0.86 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL25949948 | 0.86 | PRMT5 (0.45) | PRMT5WDR77METTL3 | |
| SCHEMBL23892470 | 0.86 | PRMT5 (0.41) | PRMT5WDR77METTL3 | |
| SCHEMBL23892522 | 0.86 | PRMT5 (0.41) | PRMT5WDR77METTL3 | |
| SCHEMBL25949786 | 0.85 | PRMT5 (0.40) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |
| WO-2017032840-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | disclosed |