⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275280 | 0.82 | SMN1; SMN2 (0.52) | — | |
| SCHEMBL10805452 | 0.79 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL26658220 | 0.79 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL23956399 | 0.77 | SMN1; SMN2 (0.39) | — | |
| Ammonia Solution, Strong SCHEMBL8809999 | 0.77 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL1920162 | 0.77 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL10559145 | 0.76 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL5632475 | 0.76 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL16847431 | 0.75 | SMN1; SMN2 (0.38) | — | |
| SCHEMBL334917 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-9110740-A | — | — | None | — | — | JP | disclosed |
| US-8383813-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2013-02-26 | — | — | US | disclosed |
| US-20120004253-A1 | Novel Fused Pyrrolocarbazoles | CEPHALON, INC. (US) | 2012-01-05 | — | — | US | disclosed |
| US-8044064-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2011-10-25 | — | — | US | disclosed |
| EP-1704148-B1 | NOVEL FUSED PYRROLOCARBAZOLES | CEPHALON INC (US) | 2011-03-02 | — | — | EP | disclosed |
| US-20100152208-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. | 2010-06-17 | — | — | US | disclosed |
| US-20100152196-A1 | Novel Fused Pyrrolocarbazoles | CEPHALON, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| US-7671064-B2 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2010-03-02 | — | — | US | disclosed |
| EP-2152719-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | Merck Frosst Canada Ltd. (CA) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008141455-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2008-11-27 | — | — | WO | disclosed |
| CN-86101066-A | Process for producing novel trifluoromethyl ketone substituted peptide derivatives | — | 1986-11-05 | — | — | CN | disclosed |
| EP-0130109-A2 | Derivatives of thiophenesulfonamide, their preparation and pharmaceutical composition for the topical treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1985-01-02 | — | — | EP | disclosed |
| US-4477466-A | Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide for the topical treatment of elevated intraocular pressure | MERCK & CO., INC. (US) | 1984-10-16 | — | — | US | disclosed |
| US-4429146-A | PRE- AND POSTEMERGENCE | GAF CORPORATION (US) | 1984-01-31 | — | — | US | disclosed |
| EP-0066106-A1 | New phenoxybenzoates, process for preparing these compounds, compositions containing them and method of use | GAF CORPORATION (US) | 1982-12-08 | — | — | EP | disclosed |
| US-4329473-A | HYPOTENSIVE AGENTS | SRI INTERNATIONAL | 1982-05-11 | — | — | US | disclosed |
| EP-0043858-A1 | HETERO RING-SUBSTITUTED OXOALKANOIC ACID DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1982-01-20 | — | — | EP | disclosed |
| EP-0001688-B1 | DERIVATIVES OF C-076 COMPOUNDS AND THEIR PREPARATION | MERCK & CO. INC. (US) | 1981-11-04 | — | — | EP | disclosed |
| US-4201861-A | Acyl derivatives of C-076 compounds | MERCK & CO., INC. (US) | 1980-05-06 | — | — | US | disclosed |
| EP-0001688-A1 | Derivatives of C-076 compounds and their preparation | MERCK & CO. INC. (US) | 1979-05-02 | — | — | EP | disclosed |