Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26045155 | 0.95 | MAPT (0.36) | MAPTMEN1KMT2APRKD3EGFR | |
| SCHEMBL21901147 | 0.75 | MEN1 (0.30) | MAPTMEN1KMT2APRKD3EGFR | |
| SCHEMBL22828956 | 0.75 | TDP1 (0.40) | MAPTMEN1KMT2APRKD3EGFR | |
| SCHEMBL26495850 | 0.75 | MAPT (0.41) | MAPTMEN1KMT2APRKD3EGFR | |
| SCHEMBL20036833 | 0.75 | MAPT (0.41) | MAPTMEN1KMT2APRKD3EGFR | |
| SCHEMBL25794401 | 0.75 | KMT2A (0.36) | MAPTMEN1KMT2APRKD3EGFR | |
| SCHEMBL24283166 | 0.73 | MAPK10 (0.37) | MAPTMEN1KMT2APRKD3EGFR | |
| SCHEMBL20418690 | 0.73 | KDM1A (0.33) | MAPTKMT2AKCNH2 | |
| SCHEMBL25804586 | 0.72 | ACP1 (0.38) | MAPTMEN1KMT2APRKD3EGFR | |
| SCHEMBL24152911 | 0.72 | TDP1 (0.39) | MAPTMEN1KMT2APRKD3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021203010-A1 | PYRROLO[2,3-F]INDAZOLE AND 2,4,5,10-TETRAZATRICYCLO[7.3.0.03,7]DODECA-1,3(7),5,8,11-PENTAENE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD) | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-10-07 | — | — | WO | disclosed |