SCHEMBL23905277

SCHEMBL23905277

CNC(=O)C1(C)COc2c1cc(C(O)(CNC(=O)c1cc(OC)c3ncc(C(F)F)cc3c1)C(F)(F)F)nc2-c1ccc(F)cc1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GABRA5 P31644 2/20 0.31
CFTR P13569 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23905285 0.94 GABRA5 (0.30) GABRA5
SCHEMBL23905289 0.93 CFTR (0.32) GABRA5CFTR
SCHEMBL23905329 0.93 GABRA5 (0.32) GABRA5CFTR
SCHEMBL23905743 0.93 GABRA5 (0.32) GABRA5CFTR
SCHEMBL23905567 0.90 CFTR (0.32) GABRA5CFTR
SCHEMBL23905580 0.90 CFTR (0.32) GABRA5CFTR
SCHEMBL23905828 0.90 CFTR (0.31) CFTR
SCHEMBL23905659 0.90 CFTR (0.31) CFTR
SCHEMBL23904795 0.90 GABRA5 (0.32) GABRA5CFTR
SCHEMBL23905318 0.90 GABRA5 (0.32) GABRA5CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021198981-A1 ANTIVIRAL COMPOUNDS AND USES THEREOF Janssen Biopharma, Inc. (US) 2021-10-07 WO disclosed