SCHEMBL23905588

SCHEMBL23905588

Cc1cc2cc(C(=O)NCC(O)(c3cc4c(c(-c5ccc(F)cc5)n3)OC[C@]4(C)C(N)=O)C(F)(F)F)cc(OC3CC3)c2nn1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CFTR P13569 2/20 0.31
GABRA5 P31644 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23904798 0.94
SCHEMBL23905280 0.94
SCHEMBL23905251 0.93 GABRA5 (0.32) CFTRGABRA5
SCHEMBL24988224 0.93 GABRA5 (0.32) CFTRGABRA5
SCHEMBL24987242 0.93 GABRA5 (0.32) CFTRGABRA5
SCHEMBL24984705 0.93 CFTR (0.31) CFTRGABRA5
SCHEMBL23905259 0.93 GABRA5 (0.32) CFTRGABRA5
SCHEMBL23905529 0.93 CFTR (0.31) CFTR
SCHEMBL25113797 0.92 CFTR (0.33) CFTRGABRA5
SCHEMBL25113796 0.92 CFTR (0.33) CFTRGABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021198981-A1 ANTIVIRAL COMPOUNDS AND USES THEREOF Janssen Biopharma, Inc. (US) 2021-10-07 WO disclosed