SCHEMBL23905735

SCHEMBL23905735

CC(C)(C)[Si](C)(C)OC[C@@]1(C)COc2c1cc(C(O)(CNC(=O)c1cc(OC3CC3)c3ncccc3c1)C(F)(F)F)nc2-c1ccc(F)c(F)c1

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GABRA5 P31644 3/20 0.32
AR P10275 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23905449 0.92 GABRA5 (0.33) GABRA5AR
SCHEMBL23905420 0.89 GABRA5 (0.33) GABRA5AR
SCHEMBL23905427 0.89 GABRA5 (0.33) GABRA5AR
SCHEMBL23904759 0.88 GABRA5 (0.32) GABRA5AR
SCHEMBL24984978 0.88 GABRA5 (0.32) GABRA5AR
SCHEMBL24984979 0.88 GABRA5 (0.32) GABRA5AR
SCHEMBL23905481 0.86 AR (0.34) GABRA5AR
SCHEMBL23905482 0.86 AR (0.34) GABRA5AR
SCHEMBL23905243 0.86 AR (0.34) GABRA5AR
SCHEMBL23905704 0.86 POLB (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021198981-A1 ANTIVIRAL COMPOUNDS AND USES THEREOF Janssen Biopharma, Inc. (US) 2021-10-07 WO disclosed