Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 4/20 | 0.46 |
| ▸ | KIT | P10721 | 4/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 8/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30086466 | 1.00 | PLK4 (0.49) | PLK4ABL1KITBCRLRRK2 | |
| SCHEMBL25222839 | 0.96 | PLK4 (0.47) | PLK4ABL1KITBCRLRRK2 | |
| SCHEMBL30086299 | 0.96 | PLK4 (0.47) | PLK4ABL1KITBCRLRRK2 | |
| SCHEMBL30086601 | 0.91 | ACVR1 (0.46) | PLK4ABL1KITBCRLRRK2 | |
| SCHEMBL23906679 | 0.91 | ACVR1 (0.46) | PLK4ABL1KITBCRLRRK2 | |
| SCHEMBL23906211 | 0.91 | GSK3B (0.47) | PLK4KITJAK2JAK3GSK3B | |
| SCHEMBL30086842 | 0.91 | GSK3B (0.47) | PLK4KITJAK2JAK3GSK3B | |
| SCHEMBL25702920 | 0.91 | JAK2 (0.51) | JAK2JAK3EGFRGSK3B | |
| SCHEMBL30086921 | 0.90 | JAK2 (0.52) | PLK4ABL1KITBCRABL2 | |
| SCHEMBL23906923 | 0.90 | JAK2 (0.52) | PLK4ABL1KITBCRABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399312-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2023-12-14 | — | — | US | disclosed |
| US-20230399312-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2023-12-14 | — | — | US | disclosed |
| US-11673879-B2 | Substituted pyrimidines and methods of use | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-06-13 | — | — | US | disclosed |
| US-11673879-B2 | Substituted pyrimidines and methods of use | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-06-13 | — | — | US | disclosed |
| WO-2021203131-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2021-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11673879-B2 | Substituted pyrimidines and methods of use | ALK, TYMP, ENTPD5 | PLK4 1890/4885ABL1 124/4885KIT 58/4885 |
| US-20230399312-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | ALK, TYMP, ENTPD5 | PLK4 1890/4885ABL1 124/4885KIT 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.