Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 7/20 | 0.45 |
| ▸ | JAK3 | P52333 | 6/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | BCR | P11274 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ABL2 | P42684 | 1/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23906679 | 1.00 | ACVR1 (0.46) | ACVR1BMPR1BNUAK1SIK2JAK2 | |
| SCHEMBL23906234 | 0.91 | PLK4 (0.49) | JAK2JAK3ABL1KITBCR | |
| SCHEMBL30086466 | 0.91 | PLK4 (0.49) | JAK2JAK3ABL1KITBCR | |
| SCHEMBL30086587 | 0.90 | JAK2 (0.55) | ACVR1BMPR1BNUAK1SIK2JAK2 | |
| SCHEMBL23906659 | 0.90 | JAK2 (0.55) | ACVR1BMPR1BNUAK1SIK2JAK2 | |
| SCHEMBL23906834 | 0.89 | CSF1R (0.56) | ACVR1BMPR1BNUAK1SIK2JAK2 | |
| SCHEMBL30086528 | 0.89 | CSF1R (0.56) | ACVR1BMPR1BNUAK1SIK2JAK2 | |
| SCHEMBL23906879 | 0.89 | JAK2 (0.45) | ACVR1BMPR1BNUAK1SIK2JAK2 | |
| SCHEMBL30086845 | 0.89 | JAK2 (0.45) | ACVR1BMPR1BNUAK1SIK2JAK2 | |
| SCHEMBL25222839 | 0.88 | PLK4 (0.47) | JAK2JAK3ABL1KITBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399312-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2023-12-14 | — | — | US | disclosed |
| US-11673879-B2 | Substituted pyrimidines and methods of use | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-06-13 | — | — | US | disclosed |
| US-20220372015-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2022-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220372015-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | ALK, TYMP, ENTPD5 | ACVR1 4/4885BMPR1B 140/4885NUAK1 2349/4885 |
| US-11673879-B2 | Substituted pyrimidines and methods of use | ALK, TYMP, ENTPD5 | ACVR1 4/4885BMPR1B 140/4885NUAK1 2349/4885 |
| US-20230399312-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | ALK, TYMP, ENTPD5 | ACVR1 4/4885BMPR1B 140/4885NUAK1 2349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.